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Abstract Tidal disruption events (TDEs) are a class of transients that occur when a star is destroyed by the tides of a massive black hole (MBH). Their rates encode valuable MBH demographic information, but this can only be extracted if accurate TDE rate predictions are available for comparisons with observed rates. In this work, we present a new, observer-friendly Python package called REPTiDE, which implements a standard loss-cone model for computing TDE rates given a stellar density distribution and an MBH mass. We apply this software to a representative sample of 91 nearby galaxies over a wide range of stellar masses with high-resolution nuclear density measurements from C. H. Hannah et al. We measure per-galaxy TDE rates ranging between 10^−7.7and 10^−2.9yr^–1and find that the sample-averaged rates agree well with observations. We find a turnover in the TDE rate as a function of both galaxy stellar mass and black hole mass, with the peak rates being observed in galaxies at a galaxy mass of 10^9.5M_⊙and a black hole mass of 10^6.5M_⊙. Despite the lower TDE rates inferred for intermediate-mass black holes, we find that they have gained a higher fraction of their mass through TDEs when compared to higher-mass black holes. This growth of lower-mass black holes through TDEs can enable us to place interesting constraints on their spins; we find maximum spins ofa_• ≈ 0.9 for black holes with masses below ∼10^5.5M_⊙. 

Aims.The scenario of feedback-free starbursts (FFB), which predicts excessively bright galaxies at cosmic dawn as observed using JWST, may provide a natural setting for black hole (BH) growth. This involves the formation of intermediate-mass seed BHs and their runaway mergers into super-massive BHs with high BH-to-stellar mass ratios and low Active Galactic Nucleus (AGN) luminosities. Methods.We present a scenario of merger-driven BH growth in FFB galaxies and study its feasibility. Results.Black hole seeds form within the building blocks of the FFB galaxies, namely, thousands of compact star clusters, each starbursting in a free-fall time of a few million years before the onset of stellar and supernova feedback. The BH seeds form by rapid core collapse in the FFB clusters, in a few free-fall times, which is sped up by the migration of massive stars due to the young, broad stellar mass function and stimulated by a “gravo-gyro” instability due to internal cluster rotation and flattening. BHs of ∼10⁴ M_⊙are expected in ∼10⁶ M_⊙FFB clusters within sub-kiloparsec galactic disks atz​ ∼ ​10. The BHs then migrate to the galaxy center by dynamical friction, hastened by the compact FFB stellar galactic disk configuration. Efficient mergers of the BH seeds will produce ∼10^6 − 8 M_⊙BHs with a BH-to-stellar mass ratio ∼0.01 byz​ ∼ ​4 − 7, as observed. The growth of the central BH by mergers can overcome the bottleneck introduced by gravitational wave recoils if the BHs inspiral within a relatively cold disk or if the escape velocity from the galaxy is boosted by a wet compaction event. Such events, common in massive galaxies at high redshifts, can also help by speeding up the inward BH migration and by providing central gas to assist with the final parsec problem. Conclusions.The cold disk version of the FFB scenario provides a feasible route for the formation of supermassive BHs. 

Autologous photoreceptor cell replacement is one of the most promising strategies currently being developed for the treatment of patients with inherited retinal degenerative blindness. Induced pluripotent stem cell–derived (iPSC-derived) retinal organoids, which faithfully recapitulate the structure of the neural retina, are an ideal source of transplantable photoreceptors required for these therapies. However, retinal organoids contain other retinal cell types, including bipolar, horizontal, and amacrine cells, which are unneeded and may reduce the potency of the final therapeutic product. Therefore, approaches for isolating fate-committed photoreceptor cells from dissociated retinal organoids are desirable. In this work, we present partial dissociation, a technique that leverages the high level of organization found in retinal organoids to enable selective enrichment of photoreceptor cells without the use of specialized equipment or reagents such as antibody labels. We demonstrate up to 90% photoreceptor cell purity by simply selecting cell fractions liberated from retinal organoids during enzymatic digestion in the absence of mechanical dissociation. Since the presented approach relies on the use of standard plasticware and commercially available current good manufacturing practice–compliant reagents, we believe that it is ideal for use in the preparation of clinical photoreceptor cell replacement therapies. 

Abstract A star that approaches a supermassive black hole (SMBH) on a circular extreme mass ratio inspiral (EMRI) can undergo Roche lobe overflow (RLOF), resulting in a phase of long-lived mass transfer onto the SMBH. If the interval separating consecutive EMRIs is less than the mass-transfer timescale driven by gravitational wave emission (typically ∼1–10 Myr), the semimajor axes of the two stars will approach each another on scales of ≲ hundreds to thousands of gravitational radii. Close flybys tidally strip gas from one or both RLOFing stars, briefly enhancing the mass-transfer rate onto the SMBH and giving rise to a flare of transient X-ray emission. If both stars reside in a common orbital plane, these close interactions will repeat on a timescale as short as hours, generating a periodic series of flares with properties (amplitudes, timescales, sources lifetimes) remarkably similar to the “quasi-periodic eruptions” (QPEs) recently observed from galactic nuclei hosting low-mass SMBHs. A cessation of QPE activity is predicted on a timescale of months to years, due to nodal precession of the EMRI orbits out of alignment by the SMBH spin. Channels for generating the requisite coplanar EMRIs include the tidal separation of binaries (Hills mechanism) or Type I inward migration through a gaseous AGN disk. Alternative stellar dynamical scenarios for QPEs, that invoke single stellar EMRIs on an eccentric orbit undergoing a runaway sequence of RLOF events, are strongly disfavored by formation rate constraints. 

ABSTRACT When a star passes close to a supermassive black hole (BH), the BH’s tidal forces rip it apart into a thin stream, leading to a tidal disruption event (TDE). In this work, we study the post-disruption phase of TDEs in general relativistic hydrodynamics (GRHD) using our GPU-accelerated code h-amr. We carry out the first grid-based simulation of a deep-penetration TDE (β = 7) with realistic system parameters: a black hole-to-star mass ratio of 106, a parabolic stellar trajectory, and a non-zero BH spin. We also carry out a simulation of a tilted TDE whose stellar orbit is inclined relative to the BH midplane. We show that for our aligned TDE, an accretion disc forms due to the dissipation of orbital energy with ∼20 per cent of the infalling material reaching the BH. The dissipation is initially dominated by violent self-intersections and later by stream–disc interactions near the pericentre. The self-intersections completely disrupt the incoming stream, resulting in five distinct self-intersection events separated by approximately 12 h and a flaring in the accretion rate. We also find that the disc is eccentric with mean eccentricity e ≈ 0.88. For our tilted TDE, we find only partial self-intersections due to nodal precession near pericentre. Although these partial intersections eject gas out of the orbital plane, an accretion disc still forms with a similar accreted fraction of the material to the aligned case. These results have important implications for disc formation in realistic tidal disruptions. For instance, the periodicity in accretion rate induced by the complete stream disruption may explain the flaring events from Swift J1644+57. 

Three centrifuge experiments were performed at the University of California, Davis, for LEAP-UCD-2017. LEAP is a collaborative effort to assess repeatability of centrifuge test results and to provide data for the validation of numerical models used to predict the effects of liquefaction. The model configuration used the same geometry as the LEAP-GWU-2015 exercise: a submerged slope of Ottawa F-65 sand inclined at 5 degrees in a rigid container. This paper focuses on presenting results from the two destructive ground motions from each of the three centrifuge models. The effect of each destructive ground motion is evaluated by accelerometer recordings, pore pressure response, and lateral deformation of the soil surface. New techniques were implemented for measuring liquefaction-induced lateral deformations using five GoPro cameras and GEO-PIV software. The methods for measuring the achieved density of the as-built model are also discussed. 

Tailed bacteriophages use a DNA-packaging motor to encapsulate their genome during viral particle assembly. The small terminase (TerS) component of this DNA-packaging machinery acts as a molecular matchmaker that recognizes both the viral genome and the main motor component, the large terminase (TerL). However, how TerS binds DNA and the TerL protein remains unclear. Here we identified gp83 of the thermophilic bacteriophage P74-26 as the TerS protein. We found that TerS P76-26 oligomerizes into a nonamer that binds DNA, stimulates TerL ATPase activity, and inhibits TerL nuclease activity. A cryo-EM structure of TerS P76-26 revealed that it forms a ring with a wide central pore and radially arrayed helix–turn–helix domains. The structure further showed that these helix–turn–helix domains, which are thought to bind DNA by wrapping the double helix around the ring, are rigidly held in an orientation distinct from that seen in other TerS proteins. This rigid arrangement of the putative DNA-binding domain imposed strong constraints on how TerS P76-26 can bind DNA. Finally, the TerS P76-26 structure lacked the conserved C-terminal β-barrel domain used by other TerS proteins for binding TerL. This suggests that a well-ordered C-terminal β-barrel domain is not required for TerS P76-26 to carry out its matchmaking function. Our work highlights a thermophilic system for studying the role of small terminase proteins in viral maturation and presents the structure of TerS P76-26 , revealing key differences between this thermophilic phage and its mesophilic counterparts.